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This digital document is an article from Phytomedicine: International Journal of Phytotherapy & Phytopharmacology, published by Urban & Fischer Verlag on June 1, 2003. The length of the article is 2791 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation Details
Title: Extracts from plants used in Mexican traditional medicine activate [Ca.sup.2+]-dependent chloride channels in Xenopus laevis oocytes.
Author: A. Rojas
Publication: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology (Refereed)
Date: June 1, 2003
Publisher: Urban & Fischer Verlag
Volume: 10 Issue: 5 Page: 416(6)Distributed by Thompson Gale
Excerpt. © Reprinted by permission. All rights reserved.
Summary The two-electrode voltage-clamp technique was employed to investigate the effects of chloroform-methanol (1:1) extracts derived from five medicinal plants on Xenopus laevis oocytes. When evaluated at concentrations of 1 to 500 [micro]g/ml, the extracts prepared from the aerial parts of Baccharis heterophylla H.B.K (Asteraceae), Chenopodium morale L. (Chenopodiaceae), Desmodium grahami Gray (Leguminosae) and Solanum rostratum Dun (Solanaceae) produced concentration-dependent oscillatory inward currents in the oocytes, while the extract of Gentiana spathacea did not induce any response. The reversal potential of the currents elicited by the active extracts was -17 [+ or -] 2 mV and was similar to the chloride equilibrium potential in oocytes. These ionic responses were independent of extracellular calcium. However, they...
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