Microbial Genomes FROM THE PUBLISHER
Genomic technologies have transformed the field of microbiology, making it possible to investigate hundreds of genomes and uncover millions of new genes. In Microbial Genomics, a panel of genomics pioneers -- many from The Institute for Genomic Research (TIGR) -- take stock of the current state of the field. Through 28 thought-provoking chapters, the authors describe some of the most common computational methods and their applications to studying pathogenic microrganisms, show how genomics can be used to reconstruct the history and dynamism of the microbial world, and discuss issues as diverse as reconstruction of metabolic pathways, cell cycle processes, microbial evolution, metagenomics, and vaccine development. Additional chapters deal with microrarrays and expression analysis and the role of genomics in drug discovery. Stimulating and comprehensive, Microbial Genomics brings together not only many of the major investigators of modern microbial genomics, but also synthesizes a coherent view of the contributions that sequencing has made to our understanding of genomic structures, evolution, and biology.
SYNOPSIS
Taking a broad approach at a relatively introductory level, this volume describes some of the most common computational tools for genomics, illustrates how genomics can be used to reconstruct the history and dynamism of the microbial world, and indicates the biological information that can be extracted by genomic studies. Horizontal gene transfer, the importance of comparative genomic analysis, and microarray-based gene expression analysis are recurring themes. Specific topics of the 28 contributions include the bioinformatics of prophage identification, comparative microbial metabolism, an overview of prokaryotic evolution and taxonomy, a survey of plant pathogen genomes, and a genomic approach to vaccine development. Annotation © 2004 Book News, Inc., Portland, OR
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