Pharmacophore Perception, Development, and Use in Drug Design (Iul Biotechnology Series)

From Book News, Inc.
In the early 1900s, Paul Ehrlich first defined pharmacophores as molecule frameworks that carry the essential features responsible for a drug's biological activity, and the modern definition is little changed. The 27 studies here begin by tracing the evolution of the concept in pharmaceutical research, then cover analog-based and receptor-based varieties, new algorithms, and the future of research. Among the specific topics: pharmacophores based on multiple common-feature alignments; modeling programs including HypoGen, DISCO, Catalyst, HipHop, GASP, Chem-X, Apex-3D, CoMFA; pharmacophore-based molecular docking, a technique for developing a pharmacophore model that accommodates inherent protein flexibility; and the effect of variable weights and tolerances on predictive model generation. Books in Print lists only one other book on the topic of pharmacophores.Book News, Inc.®, Portland, OR


Prof. Robert S. Pearlman, Chair in Pharmacy and Director, Laboratory for Molecular Graphics and Theoretical Modeling College of Pharmacy University of Texas
This book on pharmacophore perception is valuable resource in research lab and the classroom, now and for years to come.


Peter W. Sprague, Vice President for Drug Discovery, Dyax Corp
There are several technically sophisticated, yet understandable and operationally simple approaches toward pharmacophore presentation - many of them are covered.


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In the early 1900s, Paul Ehrlich first defined pharmacophores as molecule frameworks that carry the essential features responsible for a drug's biological activity, and the modern definition is little changed. The 27 studies here begin by tracing the evolution of the concept in pharmaceutical research, then cover analog-based and receptor-based varieties, new algorithms, and the future of research. Among the specific topics: pharmacophores based on multiple common-feature alignments; modeling programs including HypoGen, DISCO, Catalyst, HipHop, GASP, Chem-X, Apex-3D, CoMFA; pharmacophore-based molecular docking, a technique for developing a pharmacophore model that accommodates inherent protein flexibility; and the effect of variable weights and tolerances on predictive model generation. lists only one other book on the topic of pharmacophores. Annotation c. Book News, Inc., Portland, OR (booknews.com)


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