From Book News, Inc.
The biotechnology revolution has harnessed advanced information technology to manage its data flood. Pevsner (neuroscience and health sciences informatics, Johns Hopkins School of Medicine, Baltimore, MD) provides guidance to students on computer programs and database tools to access DNA, RNA, and protein sequencing data; functional genomics approaches to RNA and protein; and genome analysis related to disease. Includes key bioinformatics websites, part-color graphics, technical appendices, self-test quizzes with solutions, and a glossary of terms.Copyright © 2004 Book News, Inc., Portland, OR
Review
"…this appears to be an excellent textbook for graduate students and upper level undergraduate students." (Annals of Biomedical Engineering, July 2004 32,7)
"…highly recommended for academic and medical libraries, and for researchers as an introduction and reference…" (E-Streams, Vol. 7, No. 4)
“...an intriguing work targeted toward biologists wanting to solve problems...provides a compendium of many biological insights and breakthroughs and will be a useful resource...highly recommended.” (Choice, Vol. 41, No. 7, March 2004)
Review
"…this appears to be an excellent textbook for graduate students and upper level undergraduate students." (Annals of Biomedical Engineering, July 2004 32,7)
"…highly recommended for academic and medical libraries, and for researchers as an introduction and reference…" (E-Streams, Vol. 7, No. 4)
“...an intriguing work targeted toward biologists wanting to solve problems...provides a compendium of many biological insights and breakthroughs and will be a useful resource...highly recommended.” (Choice, Vol. 41, No. 7, March 2004)
Review
"I was particularly impressed by the comprehensible and comprehensive treatment of BLAST - the best that I have seen. One is guided from choosing the appropriate type of BLAST program, database and search parameters through to refining and analysing the significance of the search results--all illustrated with clear examples." (David P. Leader, University of Glasgow)
"I would not hesitate for a moment to propose Jonathan Pevsner’s new book as a standard course for biologists who need a serious, practical knowledge of modern bioinformatics. Dr. Pevsner does a masterful job at presenting virtually every major topic in bioinformatics and computational genomics, from the basics of sequence analysis, to microarray data classification, accurately and at a considerable level of detail but without any complex mathematics. In addition to being an extremely useful textbook, Pevsner’s book is a very nice read, due in large part, to carefully constructed questions and suggestions for discussion, and wonderful historical vignettes. In short, a great bioinformatics book for biologists!" (Eugene V. Koonin, Ph.D., National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland)
Book Description
Wiley is proud to announce the publication of the first ever broad-based textbook introduction to Bioinformatics and Functional Genomics by a trained biologist, experienced researcher, and award-winning instructor. In this new text, author Jonathan Pevsner, winner of the 2001 Johns Hopkins University "Teacher of the Year" award, explains problem-solving using bioinformatic approaches using real examples such as breast cancer, HIV-1, and retinal-binding protein throughout. His book includes 375 figures and over 170 tables. Each chapter includes: Problems, discussion of Pitfalls, Boxes explaining key techniques and math/stats principles, Summary, Recommended Reading list, and URLs for freely available software. The text is suitable for professionals and students at every level, including those with little to no background in computer science.
Book Info
Johns Hopkins School of Medicine, Baltimore, MD. Provides an integrative approach to understanding the theory and practice of this field. Covers sequence analysis, gene expression, microarrays, and proteomics to molecular phylogenics and whole genome studies. Shows how bioinformatics applies to biological questions at different levels. Softcover. DNLM: Computational Biology--methods.
From the Publisher
"I was particularly impressed by the comprehensible and comprehensive treatment of BLAST - the best that I have seen. One is guided from choosing the appropriate type of BLAST program, database and search parameters through to refining and analysing the significance of the search results--all illustrated with clear examples." (David P. Leader, University of Glasgow)
From the Author
Bioinformatics and Functional Genomics is a textbook for advanced undergraduate students, graduate students, and anyone involved in biomedical research. Bioinformatics represents a new field at the interface of the twentieth century revolutions in molecular biology and computers. A focus of this new discipline is the use of computer databases and computer algorithms to study proteins, genes, and the complete collections of genes that comprise an organism (genomes). A major challenge in biology is to make sense of the enormous quantities of sequence data and structural data that are being generated by genome sequencing projects and other molecular biology efforts. The tools of bioinformatics include computer programs that help to reveal fundamental mechanisms underlying biological problems related to the structure and function of macromolecules, biochemical pathways, disease processes, and evolution. The aim of the book is to explain both the theory and practice of bioinformatics and genomics. The book is especially designed to help the biologist use computer programs and databases to solve biological problems.
From the Back Cover
From the Foreword:
"For the biologists, we have an invaluable guide to the application of non-trivial tools to non-trivial biological problems . . . . For the computational/informatics community, we have . . . a critical introduction to the serious biological motivations for bioinformatics, and a resource for evaluating opportunities and progress in the field." —Russ B. Altman, Stanford University
Bioinformatics and Functional Genomics provides an important integrative approach to understanding both the theory and practice of the emerging field of bioinformatics. Broadly encompassing the field of bioinformatics, from sequence analysis, gene expression, microarrays, and proteomics to molecular phylogenics and whole genome studies, this groundbreaking text shows how bioinformatics applies to biological questions at different levels, such as gene/protein, disease, and protein structures.
Combining theoretical context with practical application, the author emphasizes practical skills, such as how to analyze genes and proteins, how to make trees using phylogenic software, how to extract data, and how to identify genes and proteins implicated in disease. In addition, the text provides: A systematic three-part format, beginning with the analysis of biological sequence data, continuing with functional genomics (from microarrays to proteomics), and ending with coverage of genomes throughout the tree of life. The subject of the human genome concludes with the latest advances in bioinformatics approaches to human disease Chapter-by-chapter problem sets, Web exercises, and Web links, as well as references to freely available software and annotated lists of recommended reading Consistent use of an example of a gene and its protein product, retinol-binding protein (RBP) Highlighted references to related studies, such as those involving breast cancer and HIV-1 Clear discussion of the positive and negative ramifications of the approaches covered
Although the text emphasizes the use of computational tools and databases, the author assumes no computational background, making this text an ideal reference for students at every level of study.
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