The Organic Chemistry of Drug Design and Drug Action
- Book Review,
by Richard B. Silverman
From Book News, Inc.
A textbook for a semester course in medicinal chemistry for senior or first-year graduate students of chemistry or biochemistry. Approaches the subject, not from the usual perspective of classes of drugs, but by the organic chemical mechanisms and effect desired when designing new drugs. Annotation copyright Book News, Inc. Portland, Or.
Review
Praise for the New Edition:
"...this book is a thorough overview of drug discovery and development... It is not only an excellent textbook for students but also a valuable resource for those already practicing medicinal chemistry."
--JOURNAL OF MEDICINAL CHEMISTRY
Praise for the First Edition:
"This book is a tour de force...appropriate for advanced undergraduate students and graduate students...strongly recommended to scientists who are seeking an efficient introduction to medicinal chemistry, background in a specific drug principle or category, or a dose of inspiration."
--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
"... unified, well-organized and clearly presented...My congratulations to Dr. Silverman in consolidating such a multiplicity of facts and data ..."
--Carl Kaiser, Director of Medicinal Chemistry, NOVA PHARMACEUTICAL CORPORATION
"The author shows an uncanny ability to present the salient principles in a systematic, well-balanced and logical way..."
--William C. Groutas, Wichita State University
"...The organization of this book and the clarity of presentation are outstanding...It is highly recommended..."
--JOURNAL OF MEDICINAL CHEMISTRY
Review
Praise for the First Edition:
"This book is a tour de force in the title area...This book would be appropriate for advanced undergraduate students and graduate students…strongly recommended to scientists who are seeking an efficient introduction to medicinal chemistry, background in a specific drug principle or category, or a dose of inspiration."
--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
"… unified, well-organized and clearly presented …It is so clearly written that it will be of value to both students and veteran scientists...My congratulations to Dr. Silverman in consolidating such a multiplicity of facts and data so as to truly begin to reduce medicinal chemistry from a hybrid of chemistry, pharmacology and related sciences to a single, clearly defined, rationalized discipline."
--Carl Kaiser, Director of Medicinal Chemistry, NOVA PHARMACEUTICAL CORPORATION
"The author shows an uncanny ability to present the salient principles in a systematic, well-balanced and logical way..."
--William C. Groutas, WICHITA STATE UNIVERSITY
"I was favorably impressed with the clarity of Dr. Silverman's writing style which made the material interesting and easy to read...Treatment of the material is quite comprehensive without being overly detailed and the referencing and illustrations are well chosen..."
--John G. Topliss, PARKE-DAVIS
"...The organization of this book and the clarity of presentation are outstanding... It is highly recommended to medicinal chemists as well as to all others entering into the field or concerned with the science of medicinal chemistry."
--JOURNAL OF MEDICINAL CHEMISTRY
Book Description
Standard medicinal chemistry courses and texts are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This book represents a new approach based on physical organic chemical principles and reaction mechanisms that rationalize drug action and allow the reader to extrapolate to many related classes of drug molecules. The Second Edition reflects the significant changes in the drug industry over the past decade, and now includes color illustrations, chapter problems, and other elements that make concepts easier to understand.
* Organic chemist's perspective of how drugs are designed and function
* Teaches organic chemists and biochemists the fundamentals of drug design and drug action using drugs as examples
* Extensive use of references to the primary and secondary literature for more in depth reading about all concepts
* Extensive use of structures, schemes, and figures to illustrate points
* Explanations of dual-acting drugs
* Problem sets and answers for each topic
* Casual writing style
* Author has published over 200 articles in the areas of synthesis, bioorganic chemistry, and medicinal chemistry, has been awarded 21 patents, and has invented a drug that is under consideration for commercialization.
Book Info
Northwestern Univ., Evanston, IL. Emphasizes the general principles of drug design and drug action from an organic chemical perspective. Includes extensive new references, color illustrations, structures, schemes, and figures. Uses both generic and tradenames and presents problems and solutions for each chapter. Previous edition: c1992. For researchers and students.
From the Back Cover
This book provides a new approach to the teaching and understanding of medicinal chemistry. It is a survey of basic principles of drug design and drug action in which the concepts are presented from a physical organic chemistry perspective so that the design, development, and mechanisms of action and metabolism of drugs can be rationally understood. The reader is then able to apply these principles to any specific classes of drugs of interest and to understand how these drugs might act at a molecular level.
KEY FEATURES
*Provides an organic and synthetic chemist's perspective of how drugs are designed and how they function
*Teaches organic chemists and biochemists the fundamentals of drug design and drug action using drugs as examples
*No prior knowledge of biochemistry, pharmacology, or physiology is assumed
*Extensive use of references to the primary and secondary literature for more in depth reading about all concepts
*Extensive use of structures, schemes, and figures to illustrate points
*Problem sets and answers are included for each topic
*Informal but clear writing style so practicing chemists and undergraduates can easily understand the concepts presented
Richard B. Silverman is professor has published over 200 articles in the areas of synthesis, bioorganic chemistry, and medicinal chemistry, has been awarded 21 patents, and has invented a drug that is under consideration for commercialization.
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